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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5c926cd81a4f0f20e350a52330fc79d1180ebb8125755d727f4cc35fcf5bc090' 
  AND token = 'LDD0ZY/x0xLYZ9FqnYWNA5nw1optFkC0FqJCxvPkBNc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00016

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}