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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'f53c1cd4915a61639108c1044dfe9fbbc18f48613f307e16c9bb6307dac5aed8' 
  AND token = 'QDRcLLXYnN2RfxoEiqgdRmxaZd7ouSK8VOFAOf2cdI4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}