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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2a245ae2166f5e37a5274d0d1766675447ac4e63242ab3638c67f38de44b3ccb' 
  AND token = 'KPg1Zd8kcVnLKzAaMZiqzgaHQlIrduDq05sDewULmcE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}