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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c8cc8402ac622db42c561f2eb4419f8680ee910bc7229ee3a8aa0b88451dc10a' 
  AND token = 'kTW2o8riT1D3PzDLsPUZ4npH8Zuhm1xbg+rRMhtGgYY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}