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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '0f61721d6b725bcf074fd0a01cc74cbdbb59b868511b2f4382d36e47d2fbd5e5' 
  AND token = 'M3YgyzcXZtYeLHXVrk44IZp51lRMV5oVwAVSgHf3Hhw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00017

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}