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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '0b66a290305d0bc3254deb0c9760790f7b4da9b6de6291ce43e430209fe45c7a' 
  AND token = '9Pcm4JESCCceFBp6wMw0oZjkh+m+trWJXGYjmd35RI0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}