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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4280ec1864ca34d1eeb4c054977dffabae597677921da452630a777689e4fd52' 
  AND token = 'S/I63Sp8oSII2w6xVB7Ax3Joe3t6aZf94tFSR2K0YIw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}