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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4c38993716d57ad4cd0ae49b16e889e6cbeaf25b6fb1d32033df765acc9bf978' 
  AND token = 'aRyA3+hd0vMsdnWuk6Y4gdyZ21nnkt3efRaE0uqU3Zo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}