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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1a495d670c0d1535439a7931986e14ccb46ca4d4533e54381a2119c81da18aed' 
  AND token = '+kVVMYgV/IFwecGllZZyWHYHAQmVLdZqllcfbdIio3I=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}