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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '460fd5847a9c7272915872e0e89719591042ae51257845d00eb59b3b49d82bc2' 
  AND token = 'KM2dUH+5hVVrTe0PSvxTUQstoa3y5RYv7oDk1TjFUHA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00015

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}