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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5efee9fa1a1ac6ef949425743e0563d637c27cfef5f1374b75e20d3bc04ba02b' 
  AND token = 'dMBLs4XeeTuxqDyNHV/jPvTXFeP2tsyaEr7vEv/aE5c=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}