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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '43d36413b561fb68fa27b9ecd79eb16f8e2f1d5afd02786892ecd19e92f27f3b' 
  AND token = '6IInHHE+fgkxh35mggnAvRLubiHbJ/RdTMlgEkpAWYI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}