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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a45f6cad8329cef7f6377e7f49b7aadc5826a1debb6ae7c9059246ea8b33141c' 
  AND token = 'XkWZOK8x+FKQJM0CR11kzzyB8rsS+z3SszGAGSk6ZLI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}