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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'f77358503ccb6c266fb96d3af8341a7e64c495465a25510ab1d82a0487026a25' 
  AND token = 'QRTYKBy7Y2/jsY0Y7Xt7GGqY8n1Z2GPs35Wpcu4cGuY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}