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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '53cf7bb31de818b3d82a255e5d9b358daff485b5d05a1285d984308c413425a7' 
  AND token = 'FL1/TcudYeUleoQf3Dz4XaOotM2liOU/LxLqyOch3Hw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}