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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2441f60d77152b37ce4aa5999869bdafde2182afa25f5cd290637464ff07e688' 
  AND token = 'OXx6i4kIH+Ql16o5HajmAMEPyGaZWNTrbPgK98Vyyfk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}