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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '456c66e621073f5e70a6f1689cb5fcab1714deef44d181db5a48547f02b3b1cf' 
  AND token = '9PMVkuA5UxnJgyMbmZX2SIpy8Q+AO1Y5wTWPInsmOfs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}