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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e165fdc1d07193fb14bab3c507c06016a2565715ab55edf83a6fbf8622b9deda' 
  AND token = 'Y+R/yCxwcWb+y0wzfuTBnC8l7sAjziV2AT4jxHS8lUc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}