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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '51943cc22c5abdb2f82246ee5cdf110021b098c1dab2f6808552bd5f5c4ca59d' 
  AND token = '+1+neLEvN+xOIQ9/YMBpNQj5vaHIBusT6cJ2j8gFc0o=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}