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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '53ab3be792095ef364dbd4d899e7295e299508332dd7013ff15644a1d9410f07' 
  AND token = 'jqIYdcoLBTxEZgR8/Y9qHiO/Q3YnB4Gsw/aaTqp7ds0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}