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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5294e3ebdf783b4a6bec29293b98e1f6f3978b576425443c864fbeff01609137' 
  AND token = 'F0ESo0Ug4zKZm76oapFx1QhDScuxDaS1PPxTQ6MB3nM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00017

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}