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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '9af0b45c99c3e95b27350b4269105df98b4ce2b5557aaaa88e1bd541b18b99a0' 
  AND token = 'PHZM3Zr/Dr499buZcfUbHIfPBNJuf2tQ+lxuvOMavhI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00017

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}