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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c61f8f5caa1e2978e8ed85a11bfbb18ab73136b7d9dad84b585c42177fd3389a' 
  AND token = 'DVzBUo+/D+ZKFCEDKUyXeedv1xFkLSSiDW5JJQ9Y6CI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00017

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}