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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'ad565b81eb4db4fb010b535fbbe49b68aeab37369c808bebda358acd92d6cd0d' 
  AND token = 'ploU8dTOByV+0ATsr68IpTs1srdVFckzuuz986bWLDg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}