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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'd4ddf8ff1d5ca6ed45466db81fece52a351d48b3974db5d16abf9b39e70dae16' 
  AND token = 'qwvE1kX7m0gUf9zF2y+iBDuHoBXfXVCxKDhWeZraDQ8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}