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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8444b4d3162d0ae946e356077ada3967a3091cad7dfa077bf80f2c4110b2015f' 
  AND token = 'fF8cH/KNZvuUaZkiPQHaGXmd/2adZaXqqBgQDc+w1Ho=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}