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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'cd8fbd8a5cc9db817c171aefbca270313eeb4d3bc425cf5f1af9165845673bf4' 
  AND token = '48UPbyxM9b4S6EGFUDPj76/TN04JkTnB4NOCRqyK5zQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}