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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'f4b4fe871edfe1d6f4c1da18d6701349b0d46e1a08011c1d340f7e6fc5122057' 
  AND token = '8Rh+dMRvG2LZpz1TYzSK2MXMkVNJNGnR/GhfKIYbvOs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}