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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '346b1c68e51ad866ed32e1e4e258bcbb1ecd7f01c4e26319f85b1cee38ee8824' 
  AND token = 'pxc5MpgFBH5oDvO/FhTFZ3UzWFWGm2nZE5MHNf0hdBQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}