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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4582a13b036f0c012a8b12b1e3a77fc3afe0507e155954407a658abe81f028f5' 
  AND token = 'KS/aRq1nFIc7dWKf7My4nZaqVbsCuNZ1J/hYqTtlfVU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00017

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}