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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '43c571168b153d5ccf3f5d732055aad6a91420d278121edbe06fbe4e9c8793c3' 
  AND token = 'NvqvMH33xEfmVSOk8jOBjoWeIJjzbqFJS627Zqn7cOM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}