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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '49dc0bde7b7791d65756295e92f4e05e0a24ecbc31c2c03c7ca432f61319b4d7' 
  AND token = 'I3Kh1rA2M84lJIP1Wsa5zATs0uliiLOKrE3qTtRb/SE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}