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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5e8c4a4292f0f8bea0431e58c25aec5d9116cf7eba899e7d6055008fc35bc243' 
  AND token = 'Hak7Qv2KGHvoL8Fm6R7A4UMlrEmq1rGfFmDczFdb5H4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00034

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}