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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '52cf8ee4b6d244826685600fb76b243af573e9193b6f27273f8eb241d463e7f6' 
  AND token = '2MVm2zyNGWcLJ+bXZ/tiWTuiLQOTBHxNwIy27/JrDmc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}