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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e350a03a945973b31f07536df4a45e9ad506baa229379e55572851999b31c886' 
  AND token = 'MtsSdZjZAHUUfHm+2+v3D1bUiCGmuwR28aqIkTNeDSM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}