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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '429c444f3f8cc94623e1dca4d90c0924ce6d8c2e9fc550dd627a360f8f676c18' 
  AND token = 'bZloVZzqxm7/UlxcUoYW1PCXVyWY7pa0S4HevOKA7Hs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}