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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '0fa11dbede29321bdb246297da3bcea0b2cecf22ed28d07f6c0537ccfa0f65ef' 
  AND token = 'M4XaEKG6OOXB97gq/km7cA6FVK6N1hD/pjY1V9aMjKE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}