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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '003207c5abc73e37cc69e35dc0b775d9cff5ef862aeb22a018f308986e7fa589' 
  AND token = 'JecyRJoE+69Dq/gk9sXXCBTUzcVvxscYHjMxWYFjXJA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}