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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b0d0944c10edafffbb84d96007a7095bb674ff8629ee68da708876c426011f8f' 
  AND token = 'niP2YbgM3NZKKqRnqC3RkdWkTEPeHv+f9NYKk/X8BoE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00014

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}