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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5edf8b43d72aaaac4cd65755dac6dbf88136e617e388cda940f3fce8540a12ea' 
  AND token = 'D20BlhRiEtp2j7xa3OYKPOqLDxkKpYnvf5qbpPG4DV4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}