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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '133dca6fa969a6e8be925b4cc9fd63b749be11686d83d57e0e215c27b6b06841' 
  AND token = 'gYzxFIL1YwqID1xweurYBMttJaS7DAKQBeQs3uTwYtQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}