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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2afb0518649ed550b6c0c2dd5d602c8d75a7b5de760e82b968804c47c47a2148' 
  AND token = 'btx0BJs3T1dx3Yqpd7MuFlQGrNXz+HC/PxERgGamdMQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00017

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}