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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5ab995befa9855966f54556dddd0605806c380bc402a43c2dcc7d3077c14f152' 
  AND token = 'KyE42B4EPLKbTYdiTMILD1xQLpPGNYYUv9FZ+ld9TVQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}