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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'f59d97d8be2fcdf4f8e6a55fbe39685f37ae587a70d2d04b1c55405a4b97d852' 
  AND token = 'yRBTP+RuA86w6tr9Pz2oOZclkb+oYdIQCVIvyy4DvdY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}