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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'bf4d921bd6d023b420a45b3a45725c084736d2ad3d102d2955d49ff6ee75091a' 
  AND token = 'WsIcZF2CU7f+w2BKTmlSLI1FyMcp3kPMnxp6Ks/3SL4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}