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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '221d4e02c7ab5c92000d6df1d21d45e5fc3f7bdbe08dab11d841eda872922f50' 
  AND token = 'Ycuxyk8oIbq/x7RdbKe0HFXUPryeoi9SGUWcvPGqRxs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}