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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'd906059da139ffc1e4e38c0f75eb6d1471fa449fa05cba67da34b1c5496c5e78' 
  AND token = 'Qv6V6MElALbNdhKz7imHtN5pB1KYk+b6ZvjbXfnaaCQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}