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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'cce5f649c27ddfdf8f421dd248b29dd23e0b903bc141f162f2dd3ae4498318c0' 
  AND token = 'i2NAo/UTSL+1FM5v0PFzcNkycuTVkis/fFdLkhW3EA0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}