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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'ebb7c9f3e62563537e7606e5d7aba778f3ecdff71df958a7f6a498637111d6dd' 
  AND token = 'tb6lfZjB0x1uy29yIR/mM9KsiyFaY3jNfWMqfuvx+yw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}