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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '52429f0622d1bce66bee956d6202e43cea9d910dcac4d6bff2b9878c06c8220d' 
  AND token = 'mlSDwTB1SDbv7l1x+zadvAbUb/FW8sabTMvF7T7VGWQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}